Current pharmacotherapies for sarcopenia
作者： Justin P. Hardee , Gordon S. Lynch
DOI: 10.1080/14656566.2019.1622093
关键词: Sarcopenia 、 Medicine 、 Intervention (counseling) 、 Intensive care medicine 、 Global health 、 Physical disability 、 Clinical trial 、 Diagnosis code 、 Population ageing 、 Skeletal muscle mass
摘要: Introduction: Sarcopenia, the age-related loss of skeletal muscle mass and function, is a global health problem that contributes to development physical disability, morbidity mortality in ageing population. Sarcopenia now recognised many countries as disease with an ICD-10-CM Diagnosis Code for billing care related this condition, despite no FDA-approved treatments being currently available. Areas covered: This review highlights current state knowledge regarding biological mechanisms contributing function provides summary existing emerging pharmacotherapies clinical trials sarcopenia. Expert opinion: While understanding pathophysiology sarcopenia has progressed, rigorous preclinical studies better inform are needed accelerate drug discovery identify safe effective treatments. Few drugs have been developed specifically failed meet clinically relevant outcomes strength performance. The multifactorial complexity means tailored, personalised more likely be required than just single intervention.
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