Insulin resistance and lipid metabolism.
作者： Barbara V Howard
DOI: 10.1016/S0002-9149(99)00355-0
关键词: Hyperinsulinemia 、 Lipid profile 、 Insulin 、 Medicine 、 Dyslipidemia 、 Cholesterol 、 Insulin resistance 、 Internal medicine 、 Lipoprotein 、 Very low-density lipoprotein 、 Endocrinology
摘要: The 3 major components of the dyslipidemia insulin resistance are increased triglyceride levels, decreased high-density lipoprotein (HDL) cholesterol, and changes in composition low-density (LDL) cholesterol. Hyperinsulinemia central obesity that typically accompanies thought to lead overproduction very (VLDL) result is more triglyceride-rich particles, fewer HDL small, dense LDL. Postprandial levels measures postprandial remnants also may contribute coronary artery disease (CAD) risk individuals with resistance. Deficiency lipase, an insulin-sensitive enzyme, might explain abnormal remnant particles potential benefits successful treatment illustrated by clinical trials patients characteristic (i.e., normal or only moderately elevated LDL, VLDL, low HDL). Both weight loss exercise can improve associated dyslipidemia. In type 2 diabetes mellitus, certain antidiabetic therapies lipid profile improving
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