Resistance to a Rhabdovirus (VHSV) in Rainbow Trout: Identification of a Major QTL Related to Innate Mechanisms

摘要: Health control is a major issue in animal breeding and better knowledge of the genetic bases resistance to diseases needed farm animals including fish. The detection quantitative trait loci (QTL) will help uncovering architecture important traits understanding mechanisms involved pathogens. We report here QTL for Viral Haemorrhagic Septicaemia Virus (VHSV), threat European aquaculture industry. Two induced mitogynogenetic doubled haploid F2 rainbow trout (Oncorhynchus mykiss) families were used. These combined genome susceptible resistant F0 breeders contained only fully homozygous individuals. For phenotyping, fish survival after an immersion challenge with virus was recorded, as well vitro replication on fin explants. A bidirectional selective genotyping strategy identified seven associated survival. One those significant at genome-wide level largely explained both viral explants different design (up 65% 49% phenotypic variance respectively). results evidence key role innate defence pave way identification gene(s) responsible resistance. also opens appealing perspectives improved