Selection for high immune response: an alternative approach to animal health maintenance?
作者： Bruce Wilkie , Bonnie Mallard
DOI: 10.1016/S0165-2427(99)00136-1
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摘要: To test the hypothesis that variation in ability to respond immunologically correlates with health, Yorkshire pigs were bred for high (HIR) and low (LIR) antibody (Ab) cell-mediated immune response (CMI). Selection was based on standardized measures of Ab (secondary hen egg white lysozyme, serum IgG concentration) CMI (cutaneous delayed-type hypersenstivity purified protein derivative tuberculin after immunization bacillus Calmette-Guerin vitro lymphocyte Con-A). Differences by line not restricted antigens used selection. Antibody vaccines highest HIR non-responders LIR pigs. The had best rate weight gain. After infection Mycoplasma hyorhinis, developed more severe arthritis less polyserositis. associated cytokine message joint-related cells. Following exposure attenuated transmissible gastroenteritis virus, natural killer cells but or control lines, unresponsive. Genetic selection may provide health productivity advantages complement traditional health-maintenance methods.
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