Non‐dermatophytes in onychomycosis of the toenails

摘要: A multicentre trial for the treatment of dermatophyte onychomycosis toenails with terbinafine was carried out in Australia and New Zealand. Between eight 12 nail samples were obtained from each 118 patients 48-week trial, sample investigated by direct microscopy culture non-dermatophyte fungi. Patients randomized to at 250 mg/day or placebo first weeks study, then non-responders offered a 12-week course week 28. All had infection. In 42 (36%) mycological identified dermatophytes alone. remaining 76 (64%), mould yeast also isolated some stage during but only three did same persist two more successive specimens. The presence fungal contaminant addition no apparent effect on efficacy terbinafine. We conclude that moulds yeasts are generally found as contaminating organisms onychomycosis, secondary dermatophytes, they do not influence outcome treatment.