The effect of chronic amphetamine treatment on cocaine-induced facilitation of intracranial self-stimulation in rats.
作者： Clayton T. Bauer , Matthew L. Banks , S. Stevens Negus
DOI: 10.1007/S00213-013-3405-1
关键词: Stimulation 、 Facilitation 、 Saline 、 Self-administration 、 Brain stimulation 、 Pharmacology 、 Psychology 、 Continuous treatment 、 Amphetamine 、 Anesthesia 、 Medial forebrain bundle
摘要: Chronic amphetamine treatment reduces cocaine self-administration in pre-clinical and clinical settings, has been proposed as a candidate medication for of abuse. The objective the present study was to investigate whether chronic can decrease abuse-related effects an assay intracranial self-stimulation (ICSS). Thirteen adult male Sprague-Dawley rats were equipped with electrodes targeting medial forebrain bundle trained lever press pulses brain stimulation “frequency-rate” ICSS procedure. Cocaine (10 mg/kg) administered before (day 0), during (days 7 14), after (posttreatment days 1 3) 2 weeks continuous either (0.32 mg/kg/h, n = 7) or saline (n = 6) via osmotic pump. Prior treatment, facilitated all rats. Saline had no effect on baseline cocaine-induced facilitation at any time. Conversely, produced sustained though submaximal ICSS, little additional treatment. Termination depression recovery ICSS. These data suggest that blunts expression
springer.com
sci-hub.se 参考文章(39)
S. Stevens Negus, Nancy K. Mello, Effects of chronic d-amphetamine treatment on cocaine- and food-maintained responding under a progressive-ratio schedule in rhesus monkeys. Psychopharmacology. ,vol. 167, pp. 324- 332 ,(2003) , 10.1007/S00213-003-1409-Y
CT Bauer, ML Banks, BE Blough, SS Negus, Use of intracranial self-stimulation to evaluate abuse-related and abuse-limiting effects of monoamine releasers in rats. British Journal of Pharmacology. ,vol. 168, pp. 850- 862 ,(2013) , 10.1111/J.1476-5381.2012.02214.X
Kyle C. Schmitt, Maarten E. A. Reith, Regulation of the dopamine transporter Annals of the New York Academy of Sciences. ,vol. 1187, pp. 316- 340 ,(2010) , 10.1111/J.1749-6632.2009.05148.X
Morgane Thomsen, Andrew C. Barrett, S. Stevens Negus, S. Barak Caine, COCAINE VERSUS FOOD CHOICE PROCEDURE IN RATS: ENVIRONMENTAL MANIPULATIONS AND EFFECTS OF AMPHETAMINE Journal of the Experimental Analysis of Behavior. ,vol. 99, pp. 211- 233 ,(2013) , 10.1002/JEAB.15
R W Wood, D C Rees, V G Laties, Stimulus control and the development of behavioral tolerance to daily injections of d-amphetamine in the rat. Journal of Pharmacology and Experimental Therapeutics. ,vol. 240, pp. 65- 73 ,(1987)
Keri A. Chiodo, Christopher M. Läck, David C. S. Roberts, Cocaine self-administration reinforced on a progressive ratio schedule decreases with continuous d-amphetamine treatment in rats Psychopharmacology. ,vol. 200, pp. 465- 473 ,(2008) , 10.1007/S00213-008-1222-8
S.Stevens Negus, Nancy K Mello, Effects of chronic d-amphetamine treatment on cocaine- and food-maintained responding under a second-order schedule in rhesus monkeys. Drug and Alcohol Dependence. ,vol. 70, pp. 39- 52 ,(2003) , 10.1016/S0376-8716(02)00339-3
Benjamin A. Zimmer, Keri A. Chiodo, David C. S. Roberts, Reduction of the reinforcing effectiveness of cocaine by continuous d -amphetamine treatment in rats: importance of active self-administration during treatment period Psychopharmacology. ,vol. 231, pp. 949- 954 ,(2014) , 10.1007/S00213-013-3305-4
Nancy J. Leith, Robert J. Barrett, Amphetamine and the reward system: evidence for tolerance and post-drug depression. Psychopharmacology. ,vol. 46, pp. 19- 25 ,(1976) , 10.1007/BF00421544
Ralph U. Esposito, Allen H.D. Motola, Conan Kornetsky, Cocaine: Acute effects of reinforcement thresholds for self-stimulation behavior to the medial forebrain bundle Pharmacology, Biochemistry and Behavior. ,vol. 8, pp. 437- 439 ,(1978) , 10.1016/0091-3057(78)90082-5