Agonist Medications for the Treatment of Cocaine Use Disorder.

摘要: Cocaine addiction is a persistent and insidious public health problem (Pomara et al, 2012). Despite evidence for sustained prevalence, clinical harm, demand treatment, the Food Drug Administration (FDA) has yet to approve any pharmacotherapy its treatment. ‘Agonist' medications such as amphetamine maintenance have emerged one intriguing but controversial class of candidates, this Circumspectives Article presents pros cons agonist treatment cocaine-use disorder. Evidence in favor will be presented by Dr Steve Negus. Negus contributed more than 20 years research on development drug-abuse he published early preclinical data supporting efficacy reduce cocaine self-administration. Regulatory challenges use Jack Henningfield. Henningfield also decades experience evaluation both abuse potential novel drugs utility candidate treatments. He was involved regulatory processes that led FDA approval various nicotine therapies buprenorphine an analgesic therapy.