Use of Preclinical Drug Vs. Food Choice Procedures to Evaluate Candidate Medications for Cocaine Addiction

摘要: Drug addiction is a disease that manifests as an inappropriate allocation of behavior towards the procurement and use abused substance away from other behaviors produce more adaptive reinforcers (e.g., exercise, work, family, social relationships). The goal treating drug not only to decrease drug-maintained but also promote reallocation alternative, nondrug reinforcers. Experimental procedures offer concurrent access both reinforcer provide research tool for assessment medication effects on choice behavioral allocation. Choice are currently standard in human laboratory medications development. Preclinical have been utilized biomedical since early 1940s, during last 10–15 years, their evaluation treat has increased. We propose here parallel preclinical clinical studies will facilitate translational development cocaine addiction. In support this proposition, review literature suggests strong concordance between effectiveness candidate modify nonhuman primates rodents these either or metrics abuse patients with disorder. strongest evidence obtained maintenance monoamine releaser d-amphetamine, agonist analogous methadone opioid nicotine formulations tobacco dependence.