Colorectal cancer chemoprevention--an overview of the science.
作者： Ernest T. Hawk , Asad Umar , Jaye L. Viner
DOI: 10.1053/J.GASTRO.2004.03.002
关键词: Intraepithelial neoplasia 、 Intensive care medicine 、 Cancer screening 、 Preventive healthcare 、 Relative risk 、 Medicine 、 Gynecology 、 Cancer prevention 、 Colorectal cancer 、 Clinical trial 、 Population
摘要: The development and dissemination of sophisticated detection technologies have recently exposed the high prevalence preinvasive colorectal neoplasia in adult U.S. population. Although cancer screening surveillance provide opportunities for risk stratification, they achieve reduction only when coupled with effective interventions. This review surveys lead compounds prevention measures by which may be prioritized clinical testing. Clinical trials remain rate-limiting step agent development, novel trial designs are needed to hasten identification testing prevention. Innovative research models include nesting end points within treatment promising preventive intended nononcologic indications.
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Hanson Pg, Chu Ww, Dietary fiber and coronary artery disease. WMJ : official publication of the State Medical Society of Wisconsin. ,vol. 99, pp. 32- 36 ,(2000)
Tetsuro Kikuchi, Yasufumi Nagata, Toshiaki Abe, In vitro and in vivo antiproliferative effects of simvastatin, an HMG-CoA reductase inhibitor, on human glioma cells Journal of Neuro-oncology. ,vol. 34, pp. 233- 239 ,(1997) , 10.1023/A:1005753523949
Bret A. Lashner, Paul A. Heidenreich, Grace L. Su, Sunanda V. Kane, Stephen B. Hanauer, Effect of folate supplementation on the incidence of dysplasia and cancer in chronic ulcerative colitis: A case-control study Gastroenterology. ,vol. 97, pp. 255- 259 ,(1989) , 10.1016/0016-5085(89)90058-9
Ruth E. Patterson, Alan R. Kristal, Marian L. Neuhouser, Vitamin Supplements and Cancer Risk Cancer Causes & Control. ,vol. 8, pp. 21- 43 ,(2001) , 10.1007/978-1-59259-039-1_2
Hixson Lj, Earnest Dl, Fennerty Mb, Sampliner Re, NSAID effect on sporadic colon polyps. The American Journal of Gastroenterology. ,vol. 88, pp. 1652- 1656 ,(1993)
Ernest T. Hawk, Jaye L. Viner, William F. Anderson, Asad Umar, Potential Role of NSAIDs and COX-2 Blockade in Cancer Therapy Humana Press, Totowa, NJ. pp. 313- 340 ,(2003) , 10.1007/978-1-59259-302-6_19
M. D. Abeloff, S. B. Baylin, A. Sjoerdsma, S. T. Rosen, G. D. Luk, M. Zeltzman, Phase II trials of alpha-difluoromethylornithine, an inhibitor of polyamine synthesis, in advanced small cell lung cancer and colon cancer. Cancer treatment reports. ,vol. 70, pp. 843- 845 ,(1986)
Douglas K. Rex, Colonoscopy: a review of its yield for cancers and adenomas by indication. The American Journal of Gastroenterology. ,vol. 90, pp. 353- 365 ,(1995) , 10.1111/J.1572-0241.1995.TB08227.X
W Troll, T H Finlay, A R Kennedy, J Yavelow, Bowman-Birk soybean protease inhibitor as an anticarcinogen Cancer Research. ,vol. 43, ,(1983)
Christopher J. Torrance, Peta E. Jackson, Elizabeth Montgomery, Kenneth W. Kinzler, Bert Vogelstein, Allan Wissner, Maria Nunes, Philip Frost, Carolyn M. Discafani, Combinatorial chemoprevention of intestinal neoplasia. Nature Medicine. ,vol. 6, pp. 1024- 1028 ,(2000) , 10.1038/79534