Protein networking in bladder cancer: immunoreactivity for FGFR3, EGFR, ERBB2, KAI1, PTEN, and RAS in normal and malignant urothelium.
作者： Ranveig Rotterud , Jahn M. Nesland , S.D Fossa
DOI: 10.14670/HH-22.349
关键词: Carcinoma 、 Urothelium 、 Urinary bladder 、 Biology 、 Immunohistochemistry 、 Bladder cancer 、 Chromosomal translocation 、 Downregulation and upregulation 、 PTEN 、 Pathology
摘要: A panel of markers, selected for the suspected bladder cancer relevance their corresponding genes, were explored expression and subcellular location in urinary tissue. The normal urothelium, non-metastasised transitional cell carcinomas (TCC), primary metastasised TCC with metastases was mapped. Potential associations between proteins identified. observations then combined a set hypotheses aimed at further hypothesis testing. Membranous ERBB4 cytoplasmic p21RAS downregulated carcinoma cells compared urothelium cells. FGFR3 translocated from cytoplasm to nucleus. ERBB2 membrane seemingly upregulated one subgroup conversely another. EGFR, KAI1 possibly PTEN revealed increased membranous immunoreactivity tumours. showed decreased nuclear staining EGFR positively correlated FGFR3. negatively expression. According our results, carcinogenesis comprises translocation nucleus, upregulation ERBB2, PTEN; downregulation p21RAS; membrane. Our results support regarding functioning as tumour suppressors cancer. may discriminate cancers. complex network factors is suggested.
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