Analysis of short- and long-term metabolic effects of growth hormone replacement therapy in adult patients with craniopharyngioma and non-functioning pituitary adenoma.
作者： E. Profka , C. Giavoli , S. Bergamaschi , E. Ferrante , E. Malchiodi
DOI: 10.1007/S40618-014-0196-0
关键词: Medicine 、 Endocrinology 、 Adult patients 、 Lipid profile 、 Glucose homeostasis 、 Craniopharyngioma 、 Pituitary adenoma 、 Metabolic syndrome 、 Insulin 、 Diabetes insipidus 、 Gastroenterology 、 Internal medicine
摘要: Adult patients operated for craniopharyngioma develop more frequently GH deficiency (GHD) than non-functioning pituitary adenoma (NFPA). The aim of the study was to compare both short- (1 year) and long-term (5 years) effects rhGH in 38 GHD adult (19 Craniopharyngioma (CP) 19 NFPA). IGF-I levels, body composition (BF %), BMI, lipid profile glucose homeostasis were evaluated all patients. Pituitary MRI performed at baseline during follow-up, as needed. At no difference between two groups observed, apart from a higher prevalence diabetes insipidus CP (79 vs 21 %). After 12 months, SDS normalized BF % significantly decreased only NFPA group. During treatment, decrease improvement shown by reduction total- LDL-cholesterol present group only, while increase insulin levels HbA1c QUICKI observed only. Accordingly, after therapy, metabolic syndrome (MS) (37 % 5 % group; p < 0.05). data suggest that are less sensitive positive on prone sensitivity worsening patients, resulting increased MS
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