DIFFERENTIAL REGULATION OF 11β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 ACTIVITY IN PATIENTS WITH DIFFERING ETIOLOGIES OF HYPOPITUITARISM
作者： Amar Agha , Lucy Ann Behan , Hannah Forde , Norman F. Taylor , Diarmuid Smith
DOI: 10.4158/EP-2018-0154
关键词: Cushing Disease 、 11β-hydroxysteroid dehydrogenase type 1 、 Cortisone 、 Hydrocortisone 、 Tetrahydrocortisone 、 Hypopituitarism 、 Tetrahydrocortisol 、 Medicine 、 Endocrinology 、 Hormone 、 Internal medicine
摘要: ABSTRACT Objective: Pituitary patients with different etiologies of hypopituitarism exhibit differing phenotypes, despite similar replacement therapy strategies. We hypothesized that differential regulation the isoenzyme 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1), which mediates net autocrine conversion cortisone to cortisol in adipose tissues and liver, may play a role. Methods: studied 11β-HSD1 activity (using urine cortisol/cortisone metabolites ratio) 36 hypopituitary treated craniopharyngiomas, remitted Cushing disease, nonfunctioning pituitary adenomas + prolactinomas on off growth hormone (GH) replacement. Results: was higher subjects craniopharyngioma both GH, as evidenced by increased tetrahydrocortisol tetrahydrocortisone metabolite ratios compared other diagnostic groups, but there no difference body mass index, insulin levels, serum measurements, or hydrocortisone dose between gro...
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