Functions of Gap Junctions in the Developing Neocortex

摘要: Gap junctions allow the direct communication between two cells via cytoplasmic connections. They are involved in every major step of neocortical development. During embryogenesis, connexins play a role cell cycle regulation and fate determination. Furthermore, they necessary for radial migration postmitotic into neocortex. Within subplate, neurons interconnected gap junctions. The synchronized activity these neuronal clusters may be important development cortical columns. postnatal period, have been found both pyramidal GABAergic interneurons. These emerge before period circuit formation experience-dependent synaptogenesis synaptic plasticity. In past decade, knowledge about functions neocortex has increased. However, comprehensive understanding functions, additional physiological information from more refined genetic mouse models is needed.