Nephrotoxicity in rats induced by chlorpryfos-ethyl and ameliorating effects of antioxidants.
作者： M Oncu , F Gultekin , E Karaöz , I Altuntas , N Delibas
DOI: 10.1191/0960327102HT225OA
关键词: Vitamin C 、 Internal medicine 、 Vitamin 、 Ascorbic acid 、 Antioxidant 、 Lipid peroxidation 、 Endocrinology 、 TBARS 、 Vitamin E 、 Glutathione peroxidase 、 Chemistry
摘要: Nephrotoxicity induced by chlorpyrifos-ethyl (CE) and ameliorating effects of melatonin vitamin E plus C were evaluated in rats exposed to CE. Experimental groups as follows: control (C), CE treated (CE), (Vit), (Mel), (Vit+CE), (Mel+CE). The the CE, Vit+CE Mel+CE administered orally with two equal doses 41 mg/kg body weight (0.25 LD50). Melatonin vitamins administrated intramuscularly at 10, 150 200 mg/kg, respectively. levels thiobarbituric acid reactive substance (TBARS) antioxidant potential (AOP), activities glutathione peroxidase (GSHPx), catalase (CAT) superoxide dismutase (SOD) studied homogenates kidney tissue. There no significant differences SOD CAT between experimental groups. level TBARS increased significantl...
sagepub.com
sci-hub.se 参考文章(35)
S. Aiolli, P. Di Simplicio, P. Dolara, M. Lodovici, A. Medica, C. Monserrat, Effect of a mixture of 15 commonly used pesticides on DNA levels of 8-hydroxy-2-deoxyguanosine and xenobiotic metabolizing enzymes in rat liver. Journal of Environmental Pathology Toxicology and Oncology. ,vol. 13, pp. 163- 168 ,(1994)
D. Sengupta, Jayati Gupta, Amit Sarkar, Chhabi Datta, Effects of organophosphorus insecticide phosphomidon on antioxidant defence components of human erythrocyte and plasma. Indian Journal of Experimental Biology. ,vol. 30, pp. 65- 67 ,(1992)
M Hidiroglou, W D Black, Pharmacokinetic study of ascorbic acid in sheep. Canadian Journal of Veterinary Research-revue Canadienne De Recherche Veterinaire. ,vol. 60, pp. 216- 221 ,(1996)
Hugo Aebi, Catalase in vitro Methods in Enzymology. ,vol. 105, pp. 121- 126 ,(1984) , 10.1016/S0076-6879(84)05016-3
Robert I. Krieger, HANDBOOK OF PESTICIDE TOXICOLOGY : Academic Press. ,(2001)
MINORU OKITA, AKIO INUI, TORU INOUE, SHIGEAKI BABA, In vitro autoradiographic localization of [3H]neuropeptide Y-binding sites in rat brain Biomedical Research-tokyo. ,vol. 11, pp. 67- 71 ,(1990) , 10.2220/BIOMEDRES.11.67
Y Kono, I Fridovich, Superoxide radical inhibits catalase. Journal of Biological Chemistry. ,vol. 257, pp. 5751- 5754 ,(1982) , 10.1016/S0021-9258(19)83842-5
Douglas Hartley, Hamish Kidd, The Agrochemicals Handbook ,(1991)
X. Song, F.J. Seidler, J.L. Saleh, J. Zhang, S. Padilla, T.A. Slotkin, Cellular Mechanisms for Developmental Toxicity of Chlorpyrifos: Targeting the Adenylyl Cyclase Signaling Cascade☆ Toxicology and Applied Pharmacology. ,vol. 145, pp. 158- 174 ,(1997) , 10.1006/TAAP.1997.8171
H.H. Draper, M. Hadley, MALONDIALDEHYDE DETERMINATION AS INDEX OF LIPID PEROXIDATION Methods in Enzymology. ,vol. 186, pp. 421- 431 ,(1990) , 10.1016/0076-6879(90)86135-I