Gastrointestinal autonomic nerve tumors: a clinical review.

摘要: Gastrointestinal autonomic nerve tumors (GANTs) are believed to be rare accounting for 1 % of all malignant gastrointestinal tumors. Many surgeons and gastroenterologists unaware this entity. This review aims highlight the salient clinical features prognosis GANTs. Using common search engines manual cross-referencing, a English literature was conducted “gastrointestinal tumor.” All published on GANTs is either case reports or small series. From 49 retrieved articles, total 107 GANT cases were collected with mean age 54 years equal male female preponderance. The most commonly affected site bowel followed by stomach. Esophageal colorectal less frequent. Clinical presentation variable ranging from non-specific symptoms, abdominal pain, weight loss, iron-deficiency anemia, obstruction bleeding. Acute due free rupture perforation subsequent peritonitis extremely rare. Endoscopic radiological investigations valuable in tumor localization determination distant spread. Thirteen patients lost had no follow-up, leaving 94 long-term outcome analysis. treated radical surgical resection involved organ as offered only hope cure. Local recurrence, metastases, both developed 40 % despite resection. Resection local recurrences hepatic metastases feasible some selected cases. Response adjuvant chemoradiation poor imatinib mesilate effective metastatic inoperable CD117-positive Radical mainstay treatment. aggressive behavior after coined response chemotherapy call urgent need develop new therapies.