Myelin Basic Protein Autoantibodies

摘要: Publisher Summary This chapter provides an overview of pathogenetic role and methods detection myelin basic protein (MBP) autoantibodies or anti-MBP antibodies, which is a major component central nervous system myelin. MBP was identified as the antigen causing experimental allergic encephalomyelitis much research has focused on its possible pathogenic target for immune attack in multiple sclerosis (MS). Elevated titers were subsequently observed cerebrospinal fluid majority patients experiencing first relapses MS well most with attacks optic neuritis. The commonly used detecting anti- are solid-phase radio immuno assay enzyme-linked immunosorbent assay. Autoantibodies to also found various neurological disorders associated demyelination. Anti-MBP potentially useful markers assessing disease activity progression demyelinating diseases.