Pathogenesis of Multiple Sclerosis—The Immune Diathesis and the Role of Viruses

摘要: Although the evidence of involvement viruses in pathogenesis MS is largely circumstantial, pattern association constant, with little for direct viral infection CNS but a consistent immune response to several common viruses. In parallel these studies, epidemiological while indicating genetic predisposition, favor an environmental pathogenetic factor and experimental models indicate that can induce demyelination either by oligodendrolysis or variety mechanisms without persistence CNS. elucidating MS, challenge understand basis abnormalities, intrathecal synthesis antibodies abnormal responses some viruses, relate MRI abnormalities which periodic BBB breakdown. There strong breakdown associated inflammation. cytokines, particularly TNF, may play role demyelination. conclusion, therefore, factors are probably key our understanding MS. These include: (i) control system its interaction antigen; (ii) related effects on cerebral endothelium including cytokine adhesion molecule regulation; (iii) glial axonal responses. Such approach not identify specific cause. It may, however, pathological cascade be "triggered" infections therapy used intervene at points response.