Prevention of Peritoneal Adhesions by Ferric Ion-Cross-Linked Hydrogels of Hyaluronic Acid Modified with Iminodiacetic Acids

摘要: We fabricated ferric ion-cross-linked hydrogels of a chelating hyaluronic acid (HA) derivative. HA was conjugated with iminodiacetic (IDA) at 22% modification degree to its disaccharide unit HA. This conjugate (HA–IDA) showed degradability by hyaluronidase even after the IDA modification, and degradation rate almost same as that HA–IDA formed (FeHA FeHA–IDA) cross-linking ions (Fe3+). The storage modulus FeHA–IDA ca. 100 Pa, which higher than 10 Pa FeHA. excellent biocompatibility mesothelium cell line well rapid degradation. Above all, efficacy in reducing adhesion formation rat sidewall defect-bowel abrasion model.