Role of extracellular signal regulated kinases 1 and 2 in neuronal survival
作者： Michal Hetman , Agata Gozdz
DOI: 10.1111/J.1432-1033.2004.04133.X
关键词: Transcriptional regulation 、 Cell biology 、 Signal transduction 、 Extracellular 、 Programmed cell death 、 Mitogen-Activated Protein Kinase 3 、 Neuroprotection 、 Biology 、 Mitogen-activated protein kinase 、 Neurotrophin
摘要: Extracellular signal regulated kinases 1 and 2 (ERK1/2) regulate cellular responses to a variety of extracellular stimuli. In the nervous system, ERK1/2 is critical for neuronal differentiation, plasticity may also modulate survival. this minireview, we present evidence that supports prosurvival activity in neurons. Several reports suggest mediates neuroprotective factors, including neurotrophins. addition, activated by injury. damaged cells, activation act as defensive mechanism helps compensate deleterious effects damaging insult. The emerging mechanisms ERK1/2-mediated neuroprotection involve transcriptional regulation and/or direct inhibition cell death machinery.
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