摘要: Neuronal apoptosis sculpts the developing brain and has a potentially important role in neurodegenerative diseases. The principal molecular components of programme neurons include Apaf-1 (apoptotic protease-activating factor 1) proteins Bcl-2 caspase families. Neurotrophins regulate neuronal through action critical protein kinase cascades, such as phosphoinositide 3-kinase/Akt mitogen-activated pathways. Similar cell-death-signalling pathways might be activated diseases by abnormal structures, amyloid fibrils Alzheimer's disease. Elucidation cell death machinery promises to provide multiple points therapeutic intervention
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