Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

作者: Gentry N. Patrick , Lawrence Zukerberg , Margareta Nikolic , Suzanne de la Monte , Pieter Dikkes

DOI: 10.1038/45159

关键词:

摘要: … profiles of p35 and Cdk5 from human brain tissues (Table 1). Whereas p35 levels were … by anti-p35 antibodies, was found to be accumulated 20–40-fold (arrowhead) compared to …

参考文章(49)
Matthew Meyerson, Greg H Enders, Chin-Lee Wu, LK Su, C Gorka, C Nelson, Ed Harlow, LH Tsai, A family of human cdc2-related protein kinases. The EMBO Journal. ,vol. 11, pp. 2909- 2917 ,(1992) , 10.1002/J.1460-2075.1992.TB05360.X
J. Biernat, E.M. Mandelkow, C. Schröter, B. Lichtenberg-Kraag, B. Steiner, B. Berling, H. Meyer, M. Mercken, A. Vandermeeren, M. Goedert, The switch of tau protein to an Alzheimer-like state includes the phosphorylation of two serine-proline motifs upstream of the microtubule binding region The EMBO Journal. ,vol. 11, pp. 1593- 1597 ,(1992) , 10.1002/J.1460-2075.1992.TB05204.X
S G Greenberg, P Davies, J D Schein, L I Binder, Hydrofluoric acid-treated tau PHF proteins display the same biochemical properties as normal tau. Journal of Biological Chemistry. ,vol. 267, pp. 564- 569 ,(1992) , 10.1016/S0021-9258(18)48531-6
Anat Shirvan, Ilan Ziv, Rina Zilkha-Falb, Tatyana Machlyn, Ari Barzilai, Eldad Melamed, Expression of Cell Cycle-Related Genes During Neuronal Apoptosis: Is there a Distinct Pattern? Neurochemical Research. ,vol. 23, pp. 767- 777 ,(1998) , 10.1023/A:1022415611545
J Lew, R.J. Winkfein, H.K. Paudel, J.H. Wang, Brain proline-directed protein kinase is a neurofilament kinase which displays high sequence homology to p34cdc2. Journal of Biological Chemistry. ,vol. 267, pp. 25922- 25926 ,(1992) , 10.1016/S0021-9258(18)35696-5
Edward C Gilmore, Toshio Ohshima, André M Goffinet, Ashok B Kulkarni, Karl Herrup, None, Cyclin-Dependent Kinase 5-Deficient Mice Demonstrate Novel Developmental Arrest in Cerebral Cortex The Journal of Neuroscience. ,vol. 18, pp. 6370- 6377 ,(1998) , 10.1523/JNEUROSCI.18-16-06370.1998
Margareta Nikolic, Margaret M. Chou, Wange Lu, Bruce J. Mayer, Li-Huei Tsai, The p35/Cdk5 kinase is a neuron-specific Rac effector that inhibits Pak1 activity Nature. ,vol. 395, pp. 194- 198 ,(1998) , 10.1038/26034
James A. Bibb, Gretchen L. Snyder, Akinori Nishi, Zhen Yan, Laurent Meijer, Allen A. Fienberg, Li-Huei Tsai, Young T. Kwon, Jean-Antoine Girault, Andrew J. Czernik, Richard L. Huganir, Hugh C. Hemmings, Angus C. Nairn, Paul Greengard, Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons Nature. ,vol. 402, pp. 669- 671 ,(1999) , 10.1038/45251
Li-Huei Tsai, V. S. Caviness, T. Takahashi, E. Harlow, Activity and expression pattern of cyclin-dependent kinase 5 in the embryonic mouse nervous system Development. ,vol. 119, pp. 1029- 1040 ,(1993) , 10.1242/DEV.119.4.1029