作者: Xiaoda Wang , Heinrich Lünsdorf , Ingrid Ehrén , Annelie Brauner , Ute Römling
DOI: 10.1007/S00284-009-9563-Z
关键词: Second messenger system 、 Biofilm 、 Urine 、 Catheter 、 Colonization 、 Escherichia coli 、 Urinary system 、 Fimbria 、 Biology 、 Microbiology
摘要: Long term catheterization of the urinary tract leads to bacterial colonization urine, whereby adherence catheter surface is a major determinative factor for colonization. Collection isolates from urine and catheters 45 patients showed multi-species catheter-colonization, while Escherichia coli were frequently found in high numbers. Biofilm formation urine-derived E. was associated with presence fluA gene, loss O-antigen, expression type 1 fimbriae. The second messenger cyclic di-GMP (cdiGMP), regulator biofilm formation, regulated selected clinical isolate suggesting that cdiGMP pathway may be target anti-biofilm therapeutic approaches.