Drug-Resistant Fungi: An Emerging Challenge Threatening Our Limited Antifungal Armamentarium.

摘要: The high clinical mortality and economic burden posed by invasive fungal infections (IFIs), along with significant agricultural crop loss caused various species, has resulted in the widespread use of antifungal agents. Selective drug pressure, attributes, host- drug-related factors have counteracted efficacy limited systemic drugs changed epidemiological landscape IFIs. Species belonging to Candida, Aspergillus, Cryptococcus, Pneumocystis are among pathogens showing notable rates resistance. Drug-resistant fungi from environment increasingly identified settings. Furthermore, we a understanding class-specific resistance mechanisms emerging Candida species. establishment stewardship programs both fields inclusion species identification, susceptibility testing, therapeutic monitoring practices clinic can minimize emergence drug-resistant fungi. New featuring promising profiles great promise treat setting. Mitigating tolerance, prelude resistance, also requires development effective fungal-specific adjuvants be used combination antifungals.