Functional polymorphisms in LPS receptors CD14 and TLR4 are not associated with disease susceptibility or Campylobacter jejuni infection in Guillain–Barré patients
作者： Karin Geleijns , Bart C Jacobs , Wouter Van Rijs , Anne P Tio-Gillen , Jon D Laman
DOI: 10.1016/J.JNEUROIM.2004.01.003
关键词: TLR4 、 Antibody 、 Serology 、 Immunology 、 Polyneuropathy 、 Campylobacter jejuni 、 Guillain-Barre syndrome 、 Campylobacter Jejuni Infection 、 Medicine 、 Pathogen 、 Immunology and Allergy 、 Neurology 、 Clinical neurology
摘要: Guillain-Barre syndrome (GBS) is an acute immune-mediated polyneuropathy preceded by infections. Campylobacter jejuni the most frequent pathogen and its lipopolysaccharide (LPS) induces antibodies cross-reactive with gangliosides. In this study we assessed whether known functional polymorphisms in LPS receptors CD14 Toll-like receptor 4 (TLR4) are associated increased susceptibility for GBS or C. serology related clinical serological features. Comparison of genotypes 242 patients 210 healthy subjects showed that TLR4 did not confer disease were infection.
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