TLR4 mutations are associated with endotoxin hyporesponsiveness in humans.
作者： Nancy C. Arbour , Eva Lorenz , Brian C. Schutte , Joseph Zabner , Joel N. Kline
DOI: 10.1038/76048
关键词: Transfection 、 In vivo 、 TLR4 、 Biology 、 Immunology 、 Pathophysiology 、 Asthma 、 Mutation 、 Lipopolysaccharide 、 Receptor
摘要: … that common mutations in TLR4 are associated with … of Tlr4 results in an LPS hyporesponsive phenotype 2 . Based on these observations, we hypothesized that mutations in TLR4 may …
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