Phenotypic differences between esophageal and gastric intestinal metaplasia

摘要: Intestinal metaplasia is a cancer precursor in the esophagus and stomach. Marked differences exist between carcinogenic processes two locations terms of natural history clinical significance. We investigated biopsies from 52 patients with Barrett's 50 gastric intestinal an attempt to throw light on their pathogenic processes. Morphologic characteristics, presence Helicobacter pylori (H. pylori), markers differentiation, inflammation, proliferation were evaluated by histochemical immunohistochemical techniques. The area covered incomplete type proportion sulfomucins significantly higher than Immunoreactivity MUC1, MUC2, MUC5AC, Das-1, cytokeratins 7 20, inducible nitric oxide synthase cyclooxygenase-2 antibodies was also greater metaplasia. In metaplasia, Das-1 cytokeratin restricted areas Cell (Ki-67) H. absent all esophagus, while it present 70% Our observations made clear that shares some phenotypic characteristics leading us suggest both could arise response injuries eventual potential. However, progression more advanced lesions be modulated nature insult.