Soluble E-selectin is not a marker of unstable coronary plaque in serum of patients with ischemic heart disease.

摘要: Increased level of soluble cell adhesion molecules may be a marker for atherosclerosis and/or reflect complication the atherosclerotic plaque. To test whether expression is more pronounced in unstable versus stable coronary plaques, we measured serum E-selectin (sE-selectin) 99 consecutive patients admitted to hospital acute syndromes (ACS) and 61 with chronic artery disease (CAD) using commercially available ELISA kit. We also sE-selectin concentration 20 sex- age-matched subjects without clinical evidence atherosclerosis, who served as controls. The mean was higher both groups compared controls (ACS, 35.0 ± 23.4 ng/mL; CAD, 32.9 21.0 controls, 14.5 6.6 one-way ANOVA, P = 0.001), but there no difference between ACS CAD. Furthermore, trend (P 0.08) toward decrease an increase extent severity In ACS, in-hospital cardiac event rate 8%. Although tended (49.2 42.1 ng/mL) than those (33.8 21.3 events, not significant. 53 C-reactive protein showed correlation concentration. These findings show that although elevated presence clinically relevant it does further during phase disease, indicating reliable indicator complicated