Effect of adrenaline and glucose on release of glucagon and insulin in vitro.

摘要: IT is well established that glucagon induces hyperglycaemia in animals and man through its action on liver glycogenolysis1 gluconeogenesis2. Adrenaline has similar metabolic effects the liver1,2 it often thought both hormones play a physiological role as glycogenolytic agents blood glucose homeostasis. Several authors, however, have reported when adrenaline was infused directly portal vein hepatic glycogenolysis were much less pronounced than hormone administeied into systemic circulation3–5. Moreover, Sokal et al. demonstrated vitro vivo that, contrast to glucagon, doses of within range had only small transient glycogen Phosphorylase activity6,7. They thus concluded agent promoting conditions suggested effect moderate might be indirect, possibly mediated stimulation secretion.