Cyst infection in autosomal dominant polycystic kidney disease: causative microorganisms and susceptibility to lipid-soluble antibiotics

摘要: Cyst infection is a frequent and serious complication of autosomal dominant polycystic kidney disease (ADPKD). Lipid-soluble antibiotics like fluoroquinolones show good penetration into cysts are recommended for cyst infection, but causative microorganisms often resistant to these agents. This study investigated the profile causing in ADPKD, their susceptibility lipid-soluble antibiotics, clinical outcomes. retrospective reviewed all ADPKD patients admitted Toranomon Hospital with diagnosis from January 2004 March 2014. All who underwent drainage had positive fluid cultures were enrolled. Patients blood satisfied our criteria or probable also There 99 episodes 93 cultures. The majority on dialysis. death rate was high when caused by multiple there infected cysts. Gram-negative bacteria accounted 74–79 % isolates groups, except hepatic Escherichia coli very low especially those hepatomegaly. Fungi detected two episodes. Fluoroquinolone-resistant showed prevalence infection. It important identify avoid overuse improve outcome ADPKD.