In vitro susceptibility of varicella-zoster virus to acyclovir.

摘要: The in vitro susceptibility of five strains varicella-zoster virus to acyclovir was examined by the plaque-reduction method human diploid lung cells. 50% effective doses ranged from 2.06 microM 6.28 a 7-day assay, with mean 3.65 microM. Irreversible inhibition plaque formtation achieved drug exceeding dose for reduction but nontoxic Studies on relative and herpes simplex types 1 2 suggested that is two- eightfold less susceptible drug. antiviral potency compared several other nucleoside analogs. Analysis metabolism virus-infected WI-38 cells revealed that, as 2, formation triphosphate forms specific viral infection.