Bacterial Hyaluronidase Promotes Ascending GBS Infection and Preterm Birth

摘要: ABSTRACT Preterm birth increases the risk of adverse outcomes and is leading cause neonatal mortality. A significant preterm in utero infection with vaginal microorganisms. These microorganisms are often recovered from amniotic fluid cases. microorganism frequently associated group B streptococcus (GBS), or Streptococcus agalactiae. However, molecular mechanisms underlying GBS ascension poorly understood. Here, we describe role hyaluronidase ascending birth. We show that clinical strains labor infections have increased activity compared to commensal obtained rectovaginal swabs healthy women. Using a murine model infection, was birth, fetal demise. Interestingly, reduced uterine inflammation but did not impact placental inflammation. Our study shows enables subvert immune responses, rates findings important implications for development therapies prevent IMPORTANCE family bacteria colonize vagina pregnant In some cases, ascend into space, injury Unfortunately, little known about infection. this study, virulence factor, HylB, higher isolated cases than those isolates discovered rely on HylB avoid detection tissue, which leads studies provide novel insight