The GSK-3β-FBXL21 Axis Contributes to Circadian TCAP Degradation and Skeletal Muscle Function

作者: Marvin Wirianto , Jiah Yang , Eunju Kim , Song Gao , Keshav Raj Paudel

DOI: 10.1016/J.CELREP.2020.108140

关键词: SarcomerePhosphorylationSkeletal muscleChemistryCircadian rhythmCryptochromeCircadian clockCell biologySCF complexUbiquitin ligase

摘要: … component TCAP as a cytoplasmic substrate of FBXL21. FBXL21 interacts with TCAP in a circadian manner antiphasic to TCAP accumulation in skeletal muscle, and circadian TCAP …

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