The F-box protein family.

摘要: The F-box is a protein motif of approximately 50 amino acids that functions as site protein-protein interaction. proteins were first characterized components SCF ubiquitin-ligase complexes (named after their main components, Skp I, Cullin, and an protein), in which they bind substrates for ubiquitin-mediated proteolysis. links the to other complex by binding core component I. have more recently been discovered function non-SCF variety cellular functions. There are 11 budding yeast, 326 predicted Caenorhabditis elegans, 22 Drosophila, at least 38 humans. often include additional carboxy-terminal motifs capable interaction; most common secondary yeast human WD repeats leucine-rich repeats, both found phosphorylated complex. majority associated motifs, these not yet defined.