Genetic variation in the cytochrome P450 epoxygenase pathway and cardiovascular disease risk

摘要: The cytochrome (CYP) P450 epoxygenase pathway catalyzes the epoxidation of arachidonic acids to epoxyeicosatrienoic acids, which are subsequently hydrolyzed less active dihydroxyeicosatrienoic by soluble epoxide hydrolase. Numerous preclinical studies have demonstrated that CYP-derived possess potent vasodilatory and anti-inflammatory properties in cardiovascular system. In humans, functionally relevant polymorphisms, may significantly modulate acid levels vivo, been identified genes encoding CYP2J2, CYP2C8, CYP2C9 Initial epidemiologic genetic variation CYP modifies disease risk at population level providing support for hypothesis modulation this represent a novel approach prevention treatment disease. Future humans validating these relationships characterizing underlying mechanisms will be necessary fully understand functional role