Mast cell lineage diversion of T lineage precursors by the essential T cell transcription factor GATA-3

摘要: GATA-3 is essential for T cell development from the earliest stages. However, abundant can drive lineage precursors to a non–T fate, depending on Notch signaling and developmental stage. Here, overexpression of blocked survival pro–T cells when Notch-Delta signals were present but enhanced viability in their absence. In fetal thymocytes at double-negative 1 (DN1) stage DN2 not those DN3 stage, rapidly induced respecification mast with high frequency by direct transcriptional 'reprogramming'. Normal also showed potential interleukin 3 stem factor added absence signaling. Our results suggest close relationship between programs previously unknown function fidelity.