Optimization of the headspace solid-phase microextraction for determination of glycol ethers by orthogonal array designs

摘要: Abstract A headspace solid-phase microextraction (HS-SPME), in conjunction with gas chromatography–flame ionization detection for use the determination of six frequently used glycol ethers at μg/l level is described. 75 μm Carboxen–polydimethylsiloxane fiber was to extract analytes from an aqueous solution. Experimental HS-SPME parameters such as extraction temperature, time, salt concentration and sample volume, were investigated optimized by orthogonal array experimental designs. The relative standard deviations reproducibility method varied 1.48 7.59%. correlation coefficients calibration curves exceeded 0.998 range least two orders magnitude. limits deionized water 0.26 3.42 μg/l. also applied analysis urine blood samples ranged 1.74 23.2