The comparative inotropic effects of six clinically used antiarrhythmic agents.

摘要: Abstract The comparative inotropic effect of propranolol, diphenylhydantoin, lidocaine, quinidine, procainamide, and bretylium on myocardial contractility was studied using the force-velocity relationship isometrically contracting cat papillary muscles. Dose-response curves over a wide concentration range were obtained. Propranolol, quinidine all produced significant depressant effects at concentrations comparable to human therapeutic blood levels. At these procainamide tosylate had little contractility, but both marked very high concentrations. When compared maximal concentration, following order decreasing negative observed: diphenylhydantin > lidocaine = propranolol procaineamide bretylium. This study emphasizes potential two drugs not commonly considered be agents.