Are herbal compounds the next frontier for alleviating learning and memory impairments? An integrative look at memory, dementia and the promising therapeutics of traditional chinese medicines.

摘要: Recent advances in neuroscience have revealed a greater, in-depth understanding of the complexities associated with memory. Contemporary theories hold that an integral relationship between memory formation, stabilization and consolidation revolve around plasticity neuronal networks. The requisite receptors α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) N-methyl-d-aspartate (NMDA) cellular mechanisms surrounding (posed to incite molecular functionality), also display strong correlations pathogenesis dementias. When brain is diseased state as result malignant neurotransmission (i.e. Alzheimer's disease; AD), homeostatic balance required for normal processes disrupted, which leads degeneration neural circuitry. Present efforts find new treatments aimed at reversing or halting neurodegeneration are immense, increasing attention being placed on investigating various herbal medicines. A wide variety plants Panax ginseng, Polygala tenuifolia, Acorus gramineus Huperzia serrata, examined here within), extracts compounds have, date, already presented advantageous results when tested against known pathogenic markers related AD-associated dementia. efficaciousness medicines appears be modulatory effect neurotrophins, kinases their substrates that, turn, initiate take part intracellular cascades processes.