Effects of piperine, cinnamic acid and gallic acid on rosuvastatin pharmacokinetics in rats.
作者： Sudipta Basu , Snehasis Jana , Vandana B. Patel , Hitesh Patel
DOI: 10.1002/PTR.4894
关键词:
摘要: The purpose of this study was to investigate the potential pharmacokinetic interactions with natural products (such as piperine (PIP), gallic acid (GA) and cinnamic (CA)) rosuvastatin (RSV) (a specific breast cancer resistance protein, BCRP substrate) in rats. In Caco2 cells, polarized transport RSV effectively inhibited by PIP, CA GA at concentration 50 μM. After per oral (p.o.) coadministration (10 mg/kg) significantly increased intravenous exposure (AUC(last)) (1 73.5%, 62.9% 53.3% (p < 0.05), respectively than alone group (control). Compared control (alone) group, p.o. (5 2.0-fold, 1.83-fold 0.05) 2.34 -fold respectively. Moreover, cumulative biliary excretion mg/kg, p.o.) decreased 53.3, 33.4 39.2% end 8 h after co-administration mg/kg), Taken together, these results indicate that such inhibit bile plasma RSV.
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