Cytochrome P450 1A1 (CYP1A1) gene polymorphisms and ovarian cancer risk: a meta-analysis.

摘要: This meta-analysis aims to examine whether the genotype status of MspI, Ile462Val, and Thr461Asn polymorphisms in Cytochrome P450 1A1 (CYP1A1) is associated with ovarian cancer risk. Eligible case–control studies were identified through search MEDLINE (end search: October 2010). Pooled odds ratios (ORs) appropriately derived from fixed effects or random models. Concerning MspI polymorphism, seven eligible (1,051 cases 1,613 controls); 11 (1,680 3,345 controls) for Ile462Val three (349 785 Thr461Asn. polymorphism seemed confer elevated risk concerning homozygous carriers (pooled OR = 2.65, 95 % CI: 1.40–5.03, p = 0.003, effects), as well at recessive model OR = 2.10, 1.13–3.92, p = 0.020, effects); these findings replicated upon Caucasian subjects. was not (for heterozygous TC vs TT pooled OR = 1.10, 0.91–1.34, p = 0.329, effects; CC vs. OR = 1.11, 0.65–1.90, p = 0.693, effects). With respect a finding borderline statistical significance emerged, pointing marginally Thr/Asn OR = 1.62, 0.97–2.70, p = 0.066, but Asn/Asn OR = 1.40, 0.18–10.89, p = 0.749, seems represent meaningful factor Caucasians. Additional high methodological quality are needed order further substantiate enrich present findings. Special attention should be paid design future studies; Asian African populations points focus.