An Elemental Correlation Study in Cancerous and Normal Breast Tissue with Successive Clinical Stages by Neutron Activation Analysis

摘要: Influence of trace elements in body metabolism and their physiological importance various diseases have motivated accurate quantitative determination biological tissues fluids. Instrumental Neutron Activation Analysis (INAA) using short long term irradiation has been employed to determine five minor (Cl, K, Na, Mg, P) 15 (As, Br, Co, Cr, Cs, Cu, Fe, Hg, Mn, Rb, Sb, Se, Sc, Sr, Zn) cancerous normal breast tissue from 30 patients four clinical stages. Several show enhancement tissue. Selenium shows maximum 94.7% followed by K (81.6%), Sc (66.7%), Cu (58.2%) Na (48.5%), P (44.4%), Zn (39.2%). Some elements, such as are depressed 30.8, 30.1, 12.8%, respectively. These compete for binding sites the cell, change its enzymatic activity exert direct or indirect action on carcinogenic process accelerating growth tumors. This is further evidenced histopathological examination cells showing poor cytological differentiation. An attempt made correlate element concentrations Zn, As, Mn ratios Se/Zn, K/P, Cu/Zn, Na/K, Se/Fe with stages cancer. Inhibition caused variation results immunological breakdown system.