Helicobacter pylori. One bacterium and a broad spectrum of human disease! An overview.

摘要: Since the historical rediscovery of gastric spiral Helicobacter pylori in mucosa patients with chronic gastritis by Warren and Marshall 1983, peptic ulcer disease has been largely viewed as being infectious aetiology. Indeed, there is a strong association between presence H. active histology. The bacterium can be isolated not less than 70% over 90% duodenal patients. Eradication organism associated histologic improvement gastritis, lower relapse rate risk bleeding from ulcer. possesses several virulence factors enabling it to survive acid milieu inside stomach possibly damaging host tissues. sequence events which might cause or still fully elucidated Koch's postulates have never fulfilled. In majority individuals, infection entirely asymptomatic no convincing data suggest an increase prevalence among these subjects. An increasingly growing body literature suggests colonization for developing mucosa-associated lymphoid tissue (MALT), MALT lymphoma, adenocarcinoma even pancreatic adenocarcinoma. implicated also number extra-gastrointestinal disorders such ischaemic heart disease, cerebrovascular atherosclerosis, skin diseases rosacea, but causal role missing. thus seems beneficial impact on human health. Various drug regimens are use eradicate involving administration three four drugs including bismuth compounds, metronidazole, clarithromycin, tetracyclines, amoxycillin, ranitidine, omeprazole 1-2 weeks. financial burden, side effects emergence resistant strains due antibiotics eradication therapy need further reconsideration.