The Arg399Gln polymorphism in the XRCC1 gene is associated with increased risk of hematological malignancies

摘要: The associations between the Arg399Gln polymorphism in X-ray repair cross-complementing gene 1 (XRCC1) and risk of hematological malignancies have been extensively investigated. However, results were inconsistent. objective current study is to investigate association by meta-analysis. We searched PubMed database, Embase CNKI Wanfang Weipu covering all studies until August 7, 2013. Statistical analysis was performed using Revman4.2 software Stata10.0 software. A total 27 case–control concerning included from 26 articles. suggested that not associated with an increased/decreased (OR = 1.15, 95 % confidence interval (CI) = 0.97–1.35, P = 0.10 for Arg/Gln + Gln/Gln vs. Arg/Arg). In subgroup ethnicity cancer types, significant found Asians (OR = 1.35, CI = 1.04–1.75, P = 0.03) but Europeans (OR = 1.07, CI = 0.86–1.33, P = 0.56), leukemia (OR = 1.25, CI = 1.02–1.54, lymphoma (OR = 0.98, CI = 0.80–1.20, P = 0.84) or myeloma (OR = 1.13, CI = 0.23–5.69, P = 0.88). meta-analysis indicated XRCC1 might be a factor leukemia. future, more large-scale are needed validate these results.