Concurrent effects of ABCB1 C3435T, ABCG2 C421A, and XRCC1 Arg194Trp genetic polymorphisms with risk of cancer, clinical output, and response to treatment with imatinib mesylate in patients with chronic myeloid leukemia.
作者： Hana Salimizand , Sabrieh Amini , Mohammad Abdi , Bayazid Ghaderi , Namam-Ali Azadi
DOI: 10.1007/S13277-015-3874-4
关键词:
摘要: There are a paucity and contradicted data about the impact of concurrent heredity polymorphic genes risk chronic myeloid leukemia (CML). In present study, effects three polymorphisms affecting integrity DNA consist ABCB1 C3435T, ABCG2 C421A, XRCC1 Arg194Trp on development were studied. Furthermore, role these in clinical laboratory outcomes patients was evaluated. this case-control 70 CML 140 healthy individuals enrolled study. The features such as phase disease response to treatment before after with imatinib mesylate collected. single nucleotide evaluated by restriction fragment length polymorphism-polymerase chain reaction. T allele Arg194Trp, C C421A significantly higher than controls. TT genotype associated development. CC421 ABCG2/TT3435 ABCG2/TT27157 also correlated CML. Patients had poor cytogenetic response, correlation diplotype accelerated significant. diplotypes might be at rapid severe have weaker treatments imatinib.
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