DNA repair gene XPD and XRCC1 polymorphisms and the risk of childhood acute lymphoblastic leukemia.

摘要: Abstract Polymorphisms have been identified in several DNA repair genes. These polymorphisms may effect capacity and modulate cancer susceptibility. In this study, we aimed to determine the four two genes, xeroderma pigmentosum complementation group D (XPD) X-ray cross-complementing 1 (XRCC1), a sample of Turkish patients with childhood acute lymphoblastic leukemia (ALL), evaluate their association ALL development. We used polymerase chain reaction (PCR) restriction fragment length polymorphism (RFLP), analyze XPD Asp312Asn, Lys751Gln, XRCC1 Arg194Trp, Arg399Gln 70 75 disease-free controls, who were similar age. No significant differences observed among study groups regard codon 312, 751, 194, 399 polymorphisms. However, combined Arg194Trp/Trp194Trp variant genotypes associated increased risk for females (OR = 5.47; 95% CI = 1.49–20.10; p  = 0.008). This finding indicates that carrying 194Trp allele are at developing ALL. results suggest be mechanisms, understanding these mechanisms will help identify individuals ALL, also should lead improved treatment