Physical Activity and High-Sensitivity C-Reactive Protein: The Multi-Ethnic Study of Atherosclerosis

摘要: Background Previous studies have suggested an inverse relationship between physical activity and markers of inflammation such as high-sensitivity C-reactive protein (hs-CRP). However, these were inconsistent, few examined whether race gender influenced the relationship. This study determined a cross-sectional association hs-CRP level in 6142 middle-aged white, Chinese, black, Hispanic participants enrolled Multi-Ethnic Study Atherosclerosis 2000–2002. Methods Combined moderate vigorous was measured by self-reported leisure, conditioning, occupational, household activities. ANCOVA used to assess moderate/vigorous race. Results Hs-CRP higher women. Blacks had highest hs-CRP, Chinese lowest. decreased across tertiles men models adjusted for age, education, site, questionnaire mode administration ( p =0.005) further smoking, infection, aspirin use =0.020). The trend remained significant after adjustment BMI; blood pressure; low-density lipoprotein cholesterol; high-density diabetes; antihypertensive, statin, diabetes medication =0.044). There downward black white men, but weaker. No clear observed any female racial/ethnic groups. Conclusions These findings suggest that differs gender. Further are needed confirm this examine mechanisms differences.