Metabolic health is a more important determinant for diabetes development than simple obesity: a 4-year retrospective longitudinal study.

摘要: Background Recent studies report the importance of metabolic health beyond obesity. The aim this study is to compare risk for diabetes development according different status and obesity over a median follow-up 48.7 months. Methods 6,748 non-diabetic subjects (mean age 43 years) were divided into four groups baseline status: metabolically healthy non-obese (MHNO), obese (MHO), unhealthy (MUHNO) (MUHO). Being was defined by having less than 2 components among 5 components, that is, high blood pressure, fasting glucose, triglyceride, low high-density lipoprotein cholesterol being in highest decile homeostasis model assessment-insulin resistance (HOMA-IR) index. Obesity assessed body mass index (BMI) higher 25 kg/m2. annually from self-questionnaire, glucose HbA1c. Results At baseline, 45.3% MHNO, 11.3% MHO, 21.7% MUHNO, MUHO. During months, 277 subject (4.1%) developed diabetes. hazard ratio 1.338 MHO group (95% CI 0.67–2.672), 4.321 MUHNO 2.702–6.910) 5.994 MUHO 3.561–10.085) when MHNO considered as reference group. These results similar after adjustment changes factors during period. Conclusion The future subgroups compared with those regardless status.