Human beta-defensins and toll-like receptors in the upper airway.
作者： S. Claeys , T. de Belder , G. Holtappels , P. Gevaert , B. Verhasselt
DOI: 10.1034/J.1398-9995.2003.00180.X
关键词: Respiratory Mucosa 、 Adenoidectomy 、 Beta defensin 、 Tonsil 、 Receptor expression 、 Immunology 、 Nasal polyps 、 Palatine tonsil 、 Medicine 、 Pathology 、 Mucous membrane of nose
摘要: Background: Measurement of innate markers in nasal mucosa, tonsils and adenoids might lead to new views about the role immunity upper airway. In this study, expression human β-defensins (HBD) 2 3 toll-like receptors (TLR) 4 various airway diseases was investigated. Methods: Surgical samples from patients with tonsillar disease (n = 18), hypertrophic (n = 10) sinonasal (n = 30) (chronic sinusitis, polyps, turbinate mucosa as controls) were investigated by immunohistochemistry. Quantification HBD-2 mRNA, TLR-2 mRNA performed real-time polymerase chain reaction (PCR). Results: Immunohistochemistry revealed a strong tissue. HBD-3 showed more than tenfold higher tissue adenoids, whereas biopsies, only negligible defensin could be measured. No significant differences found for TLR-4 between tissues, significantly lower compared other tissues. Conclusion: These results demonstrate paranasal adenoids. Toll-like receptor all these tissues illustrates possibly important immunological sentinel function mucosa.
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