Recovery of the small intestine in coeliac disease on a gluten‐free diet: Changes in intestinal permeability, small bowel morphology and T‐cell activity
作者： A. G. CUMMINS , I. A. PENTTILA , J. T. LABROOY , T. A. ROBB , G. P. DAVIDSON
DOI: 10.1111/J.1440-1746.1991.TB01145.X
关键词: Receptor 、 Coeliac disease 、 Medicine 、 Ingestion 、 Gastroenterology 、 Gluten 、 Internal medicine 、 Intestinal permeability 、 Normal diet 、 Gluten free 、 Small intestine
摘要: Intestinal permeability was assessed before and 1, 2, 4, 8 12 weeks after commencing a gluten-free diet (GFD) in eight coeliac subjects. morphology quantified six subjects on normal diet, GFD, 21 T-cell activity measured the by soluble interleukin-2 receptor (sIL-2R) concentration (normal less than 477 U/mL). increased 10-fold with geometric mean value of 0.72 decreased to 0.17 at 4 (P = 0.04), 0.07 0.010), 0.20 0.015) GFD. Two showed poor response gluten withdrawal. Quantitative intestinal no significant improvement 3 6 months Mean +/- s.d. sIL-2R concentrations were 5-fold higher control values 1400 530 U/mL 750 200 GFD 0.004). We conclude that improves rapidly majority although some abnormal persists. This may be due varying degrees ingestion resulting continued immune activation.
sci-hub.se 参考文章(34)
R V Heatley, J E Crabtree, M S Losowsky, L D Juby, P D Howdle, Serum interleukin-2-receptor in coeliac disease: response to treatment and gluten challenge. Clinical and Experimental Immunology. ,vol. 77, pp. 345- 348 ,(1989)
W E Biddison, R Yarchoan, L A Rubin, D L Nelson, C C Kurman, B Boutin, M E Fritz, Soluble interleukin 2 receptors are released from activated human lymphoid cells in vitro. Journal of Immunology. ,vol. 135, pp. 3172- 3177 ,(1985)
Elizabeth F. Bernstein, Peter F. Whitington, Successful treatment of atypical sprue in an infant with cyclosporine Gastroenterology. ,vol. 95, pp. 199- 204 ,(1988) , 10.1016/0016-5085(88)90312-5
Cyrus E. Rubin, Lloyd L. Brandborg, Patricia C. Phelps, Hawley C. Taylor, Cherill V. Murray, Richard Stemler, Cherie Howry, Wade Volwiler, Studies of celiac disease. II. The apparent irreversibility of the proximal intestinal pathology in celiac disease. Gastroenterology. ,vol. 38, pp. 517- 535 ,(1960) , 10.1016/S0016-5085(60)80027-3
W. K. DICKE, H. A. WEIJERS, J. H. v. D. KAMER, Coeliac Disease The Presence in Wheat of a Factor Having a Deleterious Effect in Cases of Coeliac Disease Acta Paediatrica. ,vol. 42, pp. 34- 42 ,(1953) , 10.1111/J.1651-2227.1953.TB05563.X
I Cobden, R J Dickinson, J Rothwell, A T Axon, Intestinal permeability assessed by excretion ratios of two molecules: results in coeliac disease. BMJ. ,vol. 2, pp. 1060- 1060 ,(1978) , 10.1136/BMJ.2.6144.1060
I. A. Penttila, C. E. Gibson, B. D. Forrest, A. G. Cummins, J. T. LaBrooy, Lymphocyte activation as measured by interleukin‐2 receptor expression to gluten fraction 111 in coeliac disease Immunology and Cell Biology. ,vol. 68, pp. 155- 160 ,(1990) , 10.1038/ICB.1990.22
James D. Perkins, David L. Nelson, Jorge Rakela, Patricia M. Grambsch, Ruud A. F. Krom, Soluble interleukin-2 receptor level as an indicator of liver allograft rejection. Transplantation. ,vol. 47, pp. 77- 81 ,(1989) , 10.1097/00007890-198901000-00018
I Bjarnason, T J Peters, In vitro determination of small intestinal permeability: demonstration of a persistent defect in patients with coeliac disease. Gut. ,vol. 25, pp. 145- 150 ,(1984) , 10.1136/GUT.25.2.145
David M. Scollard, David K. Wagner, David L. Nelson, Release of soluble interleukin-2 receptors (Tac peptide) in vivo during human immune responses to tuberculin Clinical Immunology and Immunopathology. ,vol. 46, pp. 450- 455 ,(1988) , 10.1016/0090-1229(88)90064-5