Strong agonist ligands for the T cell receptor do not mediate positive selection of functional CD8+ T cells

作者: Kristin A. Hogquist , Stephen C. Jameson , Michael J. Bevan

DOI: 10.1016/1074-7613(95)90160-4

关键词: MHC restrictionAntigenBiologyCD8Cell biologyMHC class IInternal medicineAgonistNegative selectionCytotoxic T cellMajor histocompatibility complexEndocrinology

摘要: … (SIINFEKL), and two single amino acid variants, A2 (SAINFEKL), and El (EIINFEKL), for their … of the octamer peptide SAINFEKL (A2) were added to fetal thymic organ cultures from mice …

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